中文摘要：

目的：探讨IgA肾病（IgAN）患者尿中白蛋白（Alb）、转铁蛋白（TRF）、免疫球蛋白（IgG）、α1-微球蛋白（α1-MG）、β2-微球蛋白（β2-MG）与临床及病理指标的关系。方法：采集143例原发性IgAN患者肾穿刺前新鲜晨尿,用免疫散射比浊法检测Alb、TRF、IgG、α1-MG、β2-MG的浓度;收集患者血压、血肌酐、24h尿蛋白定量以及病理分级、肾小球病变积分、肾小管间质损害积分、血管病变等资料,并进行对比分析。结果：143例IgAN患者,尿Alb、TRF、IgG、α1-MG、β2-MG升高的比例分别为95.8%、100%、91.6%、63.6%、74.1%。IgAN患者血压升高组较血压正常组尿Alb、IgG、α1-MG明显升高;肾功能异常组较肾功能正常组尿IgG、α1-MG、β2-MG明显升高。随病理Lee氏分级、肾小球硬化程度、肾小管间质损害加重,尿Alb、IgG、α1-MG明显升高;随肾小球系膜增殖程度加重,尿Alb、IgG、α1-MG以及TRF明显升高;随血管病变出现,尿α1-MG明显升高。结论：IgAN患者尿Alb、TRF、IgG、α1-MG、β2-MG与多种反应疾病进展的临床及病理指标变化一致而又各有侧重,可以更全面地反映IgAN患者肾脏病变的程度,对判断病情、随访疗效具有一定的实际意义。

英文摘要：

Objective：To study the relationships between urinary protein components and clinical- pathology characteristics in IgA nephropathy （IgAN） patients. Methods： Radioimmuno - assay was applied to detect the levels of urinary proteins components including albumin（Alb）, transferrin（TRF）, immunoglobulin （ IgG）, α1 - microglobulin （ α1 - MG）, β2 - micmglobulin （ β2 - MG） in 143 cases of IgAN patients. And the relationships between the datas and clinicalpathology characteristics were analysised. Results： The abnormal rates of Alb, TRF, IgG, α1 - MG and β2 - MG were 95.8 %, 100 %, 91.6 %, 63.6 %, 74.1%, respectively. The levels of urinary AIb,TRF, IgG,α1 - MG and β2 - MG were obviously increased with significant difference in the groups with hypertension, higher ,serum creatinine, large urinary protein, or more distinct glomerulosclerosis, tubularinterstitial lesions. The levels of urinary α1 - MG was obviously increased with significant difference in the groups of artery lesions. （All P 〈 0.05）. Conclusion：The determination of urinary Alb,TRF, IgG,α1 - MG,β2- MG may be useful to reflect clinical and pathological lesions of IgAN patients. Combined diagnosis of these urinary proteins should have clinical values.