中文摘要：

程序性坏死是近年来发现的一种由死亡受体介导的caspases非依赖性细胞死亡模式，通常在凋亡被抑制的情况下发生，具有坏死细胞的形态学特征。研究发现程序性坏死同细胞凋亡一样受细胞内信号因子的周密调节，激酶受体相互作用蛋白激酶1和受体相互作用蛋白激酶3是其关键的调控因子。程序性坏死在炎症性病变、缺血性心脑血管病、神经退行性疾病等多种疾病的发生发展及肿瘤细胞的耐药方面具有重要意义。

英文摘要：

Necroptosis is a novel programmed cell death mechanism which is caspase independent. It is mediated by specific signaling via a death receptor ligation. Necroptosis usually arises when the apoptotic pathway is inhibited, and is characterized by a necrotic morphology. Recently, many reports have revealed that necroptosis is precisely regulated by a cellular signaling pathwa）5 like apoptosis.receptor interaction protein kinase 1 and receptor interaction protein kinase 3 kinases are the key regulators of this alternative cell death mechanism. Necroptosis contributes to the pathogenesis of numerous conditions, including inflammation, ischemic injury and neurodegeneration.Moreover, it has important significance in cancer drug resistance.