副猪嗜血杆菌是引起猪格氏病的病原,多继发感染引起全身性疾病,其高发病率和死亡率给养殖业造成严重损失。作者主要对其潜在毒力因子,包括外膜蛋白ompP5和ompP2、自转运蛋白vtaA、转铁蛋白、6-磷酸葡萄糖酸脱氢酶和毒素等的研究作一综述,并对应用于副猪嗜血杆菌的最新研究方法进行概述,从而形成对其毒力相关研究较全面的认识。
Haemophilus parasuis can cause Glasser's disease in swine,which is mainly secondary infection and characterized by a polyserositis syndrome.An increase in the incidence,morbidity and mortality associated with Glasser's disease has caused significant economic losses to the pig farms.By reviewing several potential virulence factors involved in H.parasuis infection and the use of new experimental approaches,the overall knowledge of the virulence related study of H.parasuis has been gained.