欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
采用便携式拉曼光谱仪对正常、良性和恶性的乳腺癌组织进行检测，通过对其拉曼光谱的指认，归纳了其主要区别和特征．在3类乳腺组织中有明显的脂类的特征峰（1230，1268，1301，1440和1743cm2），而在良性和恶性的组织中，则出现了较为明显的蛋白（1246，1271，1315和1364cm2）和核酸（1340cm2）的特征峰．良性和恶性组织的区别在于恶性组织特有的特征峰（1340cm2），而良性组织所特有的特征峰则应归属为蛋白．在数据分析过程中，选择能够反映样本化学本质的特征峰，利用高斯过程的机器学习对特征峰值建立模型．特异性（0．94）、灵敏度（0．95）和Matthews相关系数（0．86）表明在模型中3种组织有比较良好的辨别度，对于应用拉曼光谱方法辨别正常和患病乳腺组织具有参考价值．
英文摘要：
A portable Raman spectrometer was used for distinguishing the characteristics of normal, malignant and benign fresh breast biopsy samples. Based on spectral profiles, the presence of lipids（ 1230, 1268, 1301, 1440, 1743 cm-1） is indicated in normal tissue. And proteins（amide I, and amide II1, 1246, 1271, 1315, 1364 cm-1） are found in benign and malignant tissues. Between benign and malignant, nucleic acids（ 1340 cm-l ） are found to be good discrimination parameters. In the process of data analysis, the model was set up by Gaussian Process with the intensity of the feature, and obtained the specificity （0. 94）, sensibility （0. 95 ） and Matthews correlation coefficient （ MCC, 0. 86 ）. This study shows the significance in diagnosing breast disease, and contributes fundamentally to further application on clinic.
同期刊论文项目
同项目期刊论文
Exploring type II microcalcifications in benign and premalignant breast lesions by shell-isolated na
The use of Au@SiO2 shell-isolated nanoparticle-enhanced Raman spectroscopy for human breast cancer d
Pursuing shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) for concomitant detection
Propagating and Localized Surface Plasmons in Hierarchical Metallic Structure for Surface-Enhanced R
Highly Efficient Construction of Silver Nanosphere Dimers on Poly(dimethyl siloxane) Sheets for Surf
A three-dimensional surface-enhanced Raman scattering substrate: Au nanoparticle supramolecular self
[Application of support vector machine-recursive feature elimination algorithm in Raman spectroscopy
Hierarchical Structural Nanopore Arrays Fabricated by Pre-patterning Aluminum using Nanosphere Litho
A long-range surface plasmon resonance/probe/silver nanoparticle (LRSPR-P-NP) nanoantenna configurat
Using hydroxy carboxylate to synthesize gold nanoparticles in heating and photochemical reactions an
Localized and propagating surface plasmon co-enhanced Raman spectroscopy based on evanescent field e
Enriching PMMA nanospheres with adjustable charges as novel templates for multicolored dye@PMMA nano
Long-Range Surface Plasmon Field-Enhanced Raman Scattering Spectroscopy Based on Evanescent Field Ex
Luminescent fibers: In situ synthesis of silver nanoclusters on silk via ultraviolet light-induced r
Bioidentification of biotin/avidin using surface plasmon resonance and surface-enhanced Raman scatte
Highly Efficient Construction of Silver Nanosphere Dimers on Poly(dimethylsiloxane) Sheets for Surfa
Raman spectra exploring breast tissues: Comparison of principal component analysis and support vecto
Active modulation of wavelength and radiation direction of fluorescence via liquid crystal-tuned sur
Tunable Plasmons in Shallow Silver Nanowell Arrays for Directional Surface-Enhanced Raman Scattering
期刊信息
位置：