中文摘要：

分子识别是生物体系的基本特征，并在生命活动中起中心作用。生物酶高效专一地催化生化反应，抗体与抗原的结合，蛋白质分子与DNA序列的相互作用等都源于精确的分子识别。利用合成的人工受体与适当底物之间的分子识别以建立仿生仿酶模型的研究，已成为生物有机化学前沿富有挑战性的领域。分子裂缝作为一类新型的人工受体，以其灵活的结构以及易于将功能团聚集在受体与底物结合的活性部位上等优点，引起了人们的广泛关注口。胆甾因其具有刚性的凹面结构和天然的手性，

英文摘要：

A novel type of ehiral molecular clefts was designed and synthesized by using ehenodeoxyeholic acid as spacer and aromarie compounds as arm. Their structures were confirmed by ^1H NMR, IR, MS spectra and elemental analysis. Enanrioseleetive recognition properties of these molecular clefts for amino acid methyl esters were investigated by UV-vis spectra titration. The resuits indicated that these molecular clefts not only recognize all amino acid methyl esters examined but also possess higher selectivity for L-amino acid methyl esters than for D-amino acid methyl esters.