中文摘要：

1A6/DRIM 作为 UTP20 被识别了，一个小子单元 processome 部件，在 18S rRNA 处理工作。在现在的学习，当 1A6/DRIM 是在 HeLa 房间的 silenced 时， 28S rRNA 和 5.8S rRNA 的成熟被禁止；并且巧合地， 32S rRNA 先锋的累积被观察。Immunoprecipitation 与 anti-1A6/DRIM 抗体被执行，与 ITS2 探查由北污点列在后面。结果证明 1A6/DRIM 在 vivo 与 32S 和 12S rRNA 先锋被联系。1A6/DRIM 的表示侧面被蔗糖密度坡度分别与西方的污点分析在联合在 rRNA 处理期间调查。结果证明 1A6/DRIM 在核与 32S 和 12S rRNA 先锋除了 pre-40S 粒子和合作沉积涉及 pre-60S 粒子。而且，有 1A6/DRIM 的 U8 snoRNA 的相互作用被 immunoprecipitation 揭示。这些结果证明 1A6/DRIM 与 32S rRNA 和 U8 snoRNA 交往了，涉及 28S rRNA 并且 5.8S rRNA 处理。

英文摘要：

1A6/DRIM has been identified as UTP20, a small subunit processome component, functioning in 18S rRNA processing. In the present study, the maturation of 28S rRNA and 5.8S rRNA was inhibited when 1A6/DRIM was silenced in HeLa cells; and coincidently, an accumulation of 32S rRNA precursor was observed. Immunoprecipitation was performed with the anti-lA6/DRIM antibody, followed by Northern blot with the ITS2 probe. The results showed that 1A6/DRIM was associated with both 32S and 12S rRNA precursors in vivo. The expression profile of 1A6/DRIM during rRNA processing was investigated by sucrose density gradient fractionation in combination with Western blot analysis. The results demonstrated that 1A6/DRIM was involved in the pre-60S particles in addition to the pre-40S particles and co-sediment with the 32S and 12S rRNA precursors in the nucleolus. Furthermore, the interaction of U8 snoRNA with 1A6/DRIM was revealed by immunoprecipitation. These results demonstrated that 1A6/DRIM interacted with both 32S rRNA and U8 snoRNA, being involved in 28S rRNA and 5.8S rRNA processing.