中文摘要：

目的：探讨跑台运动对幼龄大鼠海马齿状回神经再生的影响.方法：选取20只5周龄SD大鼠,将其随机分为1周对照组、1周运动组、2周对照组和2周运动组.运动组大鼠以小强度分别进行为期1周和2周的跑台运动.实验后,大鼠腹腔注射溴脱氧尿嘧啶核苷（bromodeoxyuridine,BrdU）,使用免疫组织化学方法检测分析大鼠脑内海马齿状回（dentate gyrus,DG）和脑部扣带回（cingulate gyrus,CG）神经细胞的再生情况.结果：各组大鼠脑部海马齿状回和脑部扣带回均出现BrdU标记的阳性细胞,说明此区有新的神经细胞生成;其中1周运动组大鼠齿状回中的BrdU阳性细胞数显著多于1周对照组（P＜0.05）;2周运动组大鼠海马齿状回中的BrdU阳性细胞数与2周对照组相比无显著性差异（P＞0.05）.此外,两个运动组大鼠脑部扣带回的BrdU阳性细胞数与相应的对照组之间无显著性差异（P＞0.05）.结论：1周小强度跑台运动可促进幼龄大鼠脑部海马齿状回区的神经再生.

英文摘要：

Objective To explore the effect of treadmill running on neurogenesis in the hippoeampal dentate gyms of young rats. Methods Male Sprague - Dawley rats（5 weeks of age） were used for the experiment; and they were divided into the 1 - week control, 1 - week- exercise, 2 - week control, and 2 - week - exercise groups. The two exercise groups were force to mn on treadmill for 1 week or 2 weeks with low exercise load. The neurogenesis in the dentate gyms and cingnlate gyms were investigated with immunohistochemistry via intraperitoneal injection of 5 - bromo- 2＇ - deoxyuridine（BrdU） . Results The results of immunohistochemisty showed that many BrdU - labeled cells in the dentate gyms and cingnlate gyms of all groups appeared. There were also newly generated cell in these areas. And the number of BrdU - positive cells in the dentate gyms of the 1 - week - exercise group were more than that of the 1 - week control group （ P 〈 0.05） ; while there was no significant difference in the number of BrdU- positive ceils in the dentate gyms between the 2- week control and the 2 - week - exercise groups（ P 〉 0.05）. Furthermore, there was no significant difference in the number of BrdU - positive cells in cingnlate gyms between the control and the corresponding exercise groups（ P 〉 0.05）. Conclusion Treadmill running with low load for 1 week can enhance neurogenesis in the dentate gyms of young SD rats.