中文摘要：

尿苷-5＇-二磷酸葡萄糖醛酸转移酶（UGT）是药物II相代谢反应最主要的酶,通过催化葡萄糖醛酸与内源性或外源性化学物质发生葡萄糖醛酸化反应,进而影响药物的药代动力学特征。许多植物药及其有效成分是UGT的底物,由UGT介导其催化代谢。本文概述了UGT酶介导某些植物药及其组分的催化代谢和对UGT酶活性的影响。

英文摘要：

Uridine 5＇- diphosphate glucuronosyltransferases（ UGT） are the most important phase II drug metabolizing enzymes. They catalyze the glucuronidation of endogenous or exogenous chemicals,which then affect the pharmacokinetic characteristics of co- administrated drugs. Many herbs as well as their active ingredients are the substrates of UGT and their catalytic metabolism are mediated by UGT. This paper summarizes the catalytic metabolism of some herbs and their components mediated by UGT and their influence on UGT activity.