中文摘要：

磺脲类口服降糖药在人体内主要经过肝脏代谢。肝脏中的细胞色素氧化酶P450是一种重要的药物代谢酶系统,在人群中存在基因多态性,导致药物疗效和不良反应在个体间存在着较大的差异。本文将对CYP450中的几种重要的代谢酶亚型CYP2C9、CYP2C19、CYP3A4的基本结构、基因多态性、种族差异及其对磺脲类降糖药代谢的影响作一综述。

英文摘要：

Sulfonylurea oral antidiabetic drugs were mainly metabolized by hepatic cyto- chrome P450 in human. Cytochrome P450 is one kind of important drug metabolizing enzymes in human and exhibits genetic polymorphism, which usually results in the difference of efficacy and adverse reaction among individuals. The pur- pose of this paper was to review the basic struc-ture, genetic polymorphism and ethnic difference of CYP2Cg, CYP2C19, CYP3A4 and the influ ence to sulfonylurea metabolism.