中文摘要：

嵌合抗原受体是一种基础性的免疫治疗,经过近二十五年的发展,它已经成了治疗恶性肿瘤的新希望。随着对新的特异性肿瘤标志物的不断发现以及基因工程技术的不断发展,嵌合抗原受体技术越来越成熟,即将在临床上得到广泛应用。嵌合抗原受体技术治疗方法在血液肿瘤的治疗中存在显著的优势,取得了新的突破。本文主要对嵌合抗原受体技术在血液肿瘤免疫治疗中的应用进行回顾性分析,对其优势、创新、应用现状以及未来发展进行了深入分析。

英文摘要：

As a basic immune treatment strategy. Chimeric antigen receptor has nearly 25-years history in the treatment of malignant tumors. With the development of signal transduction pathways, chimeric antigen receptors are widely used in clinical practice. In the treatment of hematological malignancies, chimeric antigen receptors have some significant advantages. The chimeric antigen receptors were retrospectively analysis on the innovation, application, statusquo and development situation, one by one comb.