中文摘要：

LPS是革兰氏阴性菌的细胞壁主要组成成分,细菌死亡溶解或用人工方法破坏菌细胞后才释放出来。其毒性成分主要为类脂质A,能够引起哺乳动物细胞发生免疫反应,从而导致促炎因子的释放。通过细胞表面的先天免疫分子受体识别LPS是感染性休克的重要过程。严重感染,如肺炎、脓毒血症等是进入重症监护室的主要原因。LPS受体的识别、信号转导机制的研究是解决感染引起的炎症反应的重要环节,理解类脂A的生化修饰过程及其在发病机理过程中的作用可为这类疾病的治疗提供新的治疗方法。

英文摘要：

Lipopolysaccharide（LPS） is a major component of the cell wall ofgram-negative bacteria. Bacterial death or dissolved by artificial methodsafter the destruction of bacterial cells released. Lipid A is known to beresponsibIc for the toxic effects of infections on mammalian cell immuneresponse and then leading to promote inflammatory factor released. Identificationof LPS by innate immune molecule receptors on the cell surface is an importantprocess of septic shock. Infection is the invasion of an organisms bodytissues by disease-cansing agents, their multiplication, and the reaction ofhost tissues to these organisms and the toxins they produce and very common in clinical. Severe infections, such as pneumonia, sepsis are the main reasons for enteringthe intensive care unit. The recognition of LPS receptors and the study ofsignal transduction mechanism are important steps to solve the inflammatoryreaction induced by infection, understanding the biochemistry of lipid A modifieationsand their impact on pathogenesis could lead to novel treatment options forthese diseases.