目的探讨不稳定性心绞痛(UAP)证素与黏附分子之间的规律。方法收集265例UAP患者四诊信息,以因子分析归纳证素,用决策树探讨证素与黏附分子的关系。结果因子分析得到7个证素,频率高至低依序为血瘀、气虚、痰浊、热蕴、气滞、阴虚、阳虚。sP选择素(sP-sel)与瘀血血管黏附分子(sVCAM-1)与痰瘀关系密切。结论黏附分子可辅助作为筛选UAP的早期标志之一,痰瘀的微观实质可能与黏附分子之间存在某种内在联系。
Objective To discuss the relation between traditional Chinese medicine(TCM)syndrome factors and adhesion mole- cules in unstable angina pectoris(UAP). Methods TCM syndrome diagnostic information was collected in 265 cases with UAP. Fac- tor analysis was used to summarize the syndrome elements. The relationship between the TCM syndrome factors and adhesion mole- cules was analyzed by decision tree. Results There were 7 syndrome elements including the blood stasis,qi deficiency,turbid phlegm, heat, qi stagnation, yin deficiency,and yang deficiency. The soluble platelet selectin (sP- sel) was related closely with blood stasis, and soluble vascular cell adhesion molecule- I(sVCAM - 1) was related with phlegm and blood stasis. Conclusion Adhesion molecules might be one of the early signs of UAP. There was certain relationship between the microscopic essence of phlegm, blood stasis, and adhesion molecules.