中文摘要：

骨髓含有内皮祖细胞,能够迁移至外周血并分化为成熟内皮细胞,参与胚胎时期的血管生成、出生后的微血管新生以及肿瘤组织的发生。体内内皮祖细胞数量和活性受多种生理性及病理性因素的的影响。体外扩增后回输体内可以修复受损组织、器官的血管,促进器官功能恢复;抑制其活性,在一定程度上可以抑制肿瘤组织的生长。内皮祖细胞为缺血性疾病以及肿瘤的治疗提供了另一新的靶点。

英文摘要：

The bone marrow contains endothelial progenitor cells which could migrate to the peripheral blood and differentiate into the mature endothelial cells. The endothelial progenitor cell＇s participate in the angiogenesis, the postnatal vascularization and the tumor generation. Researches have found that numerous physiological and pathological factors influenced the number and function of endothelial progenitor cells. Transplantantion of endothelial progenitor cells could repair the injuried vessel, thus promoting the recovery of the organ function. Blockage of endothelial progenitor cells could inhibit the growth of tumor. More and more studies proved that the endothelial progenitor cells provide a therapeutic stratagy for the ischemic diseases and the tumor.