以6-氯嘌呤,6-氯嘌呤核苷或8-溴嘌呤核苷为原料,微波辐射下与水合肼反应生成相应的6-肼嘌呤(2a~2e),6-肼嘌呤核苷(2f和2g)或8-肼嘌呤核苷(2h和2i);2在微波辐射下经Wolff-Kishner-HuangMinlon还原反应得到6-脱氯嘌呤,6-脱氯嘌呤核苷或8-脱溴嘌呤核苷,总收率46%~83%,其结构经1HNMR和13CNMR表征。
6-chloropurine,6-chloropurine nucleosides or 8-bromopurine nucleosides as starting materials reacted with hydrazine monohydrate under microwave irridiation,giving the corresponding substituted product.Then the dehalogenated purine and purine nucleosides were synthesized from them via Wolff-Kishner-Huang Minlon reductive reaction under microwave irradiation and the yields were from 46% to 83%.The structures were characterized by 1H NMR and 13C NMR.