以嘌呤碱基和各种α,β-不饱和醛为原料,用三乙胺作为催化剂,在微波的促进下,通过Michael加成反应和原位还原,高效地合成了一系列非环核苷类新化合物.得到的目标化合物通过核磁共振图谱、高分辨质谱进行了确认.
Acyclic purine nucleosides were synthesized in good to high yields via Michael addition reaction of purine bases and α,β-unsaturated aldehydes under microwave irradiation and reduced by NaBH4 in situ.The structures of all compounds are characterized by NMR and HRMS techniques.