New approach to paricalcitol synthesis
- ISSN号:1001-6538
- 期刊名称:Chinese Science Bulletin (IF: 0.898)
- 时间:0
- 页码:1217-1220
- 语言:英文
- 分类:O629.9[理学—有机化学;理学—化学] O413[理学—理论物理;理学—物理]
- 作者机构:[1]State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China
- 相关基金:Acknowledgement We are grateful to the financial support of the Na- tional Natural Science Foundation of China (Nos. 21072084, 21272099) and Fundamental Research Founds for the Central Universities (No. lzujbky-2010- 107). We also thank Prof. Quanxiang Wu of Lanzhou University for helpful discussions.
- 相关项目:雷公藤乙素及其类似物的不对称合成与抗肿瘤构效关系研究
关键词:
全合成, 结构, 核磁共振实验, 目标分子, 生物碱, 喹唑啉, 内酰胺, 吲哚, orisuaveolines A and B, indoloquinazoline alkaloids, Pictet-Spengler reaction, one-pot condensation
中文摘要:
-indoloquinazoline 碱 orisuaveolines A 和 B 的建议结构的第一全部的合成被报导。合成的关键步包括了 Pictet-Spengler 反应造进一步转变了成由一个一个壶冷凝作用分子的目标的六成员的酮。这合成从便宜、商业地可得到的开始的材料以一种短、方便的方式提供了存取给 orisuaveolines A 和 B 的建议结构。我们的综合产品的结构被 2D-NMR 实验证实。
英文摘要:
First total synthesis of the proposed structures of β-indoloquinazoline alkaloids orisuaveolines A and B is re- ported. The key steps of the synthesis included a Pictet-Spengler reaction to build a six-member lactam which fur- ther transformed into target molecular by a one-pot condensation. This synthesis provided an access to the proposed structures of orisuaveolines A and B in a short and convenient manner from inexpensive, commercially available starting materials. The structures of our synthesized products were confirmed by 2D-NMR experiments.