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中文摘要：
单核-巨噬细胞具有强大的吞噬功能,在机体固有免疫和适应性免疫中均发挥着重要作用,可有效保护宿主免受多种致病菌的感染。病原菌在与宿主单核-巨噬细胞的长期相互作用过程中,逐渐形成多种逃避杀灭的有效策略,得以在宿主体内存活并增殖。本文从病原菌抗巨噬细胞吞噬作用、抗巨噬细胞内吞噬溶酶体降解作用、诱导和抑制巨噬细胞凋亡或坏死4个方面,综述近年来国内、外关于病原菌逃避单核-巨噬细胞杀灭策略的研究进展。
英文摘要：
Mononuclear macrophages,which protect people from many infections,play a pivotal role both in innate immunity and acquired immunity.Meanwhile,in order to evade killing by mononuclear macrophages,bacteria have evolved several effective strategies to survive and colonize in the host.This review summarizes various ways that pathogenic bacteria evade killing by mononuclear macrophages including （1） anti-phagocytosis,（2） anti-degradation of phagolysosomes,（3） inducing apoptosis or necrosis of the macrophages,and （4） inhibiting apoptosis or necrosis of the macrophages.
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