中文摘要：

非酒精性脂肪性肝病（NAFLD）已成为影响我国人民生活的最主要的慢性肝病。近年来,中医药在非酒精性脂肪性肝炎（NASH）的治疗中逐渐显示出一定的优势。本文基于NASH临床典型证候分析,并运用＂以方测证＂的病机研究方法,结合团队近年来以清热祛湿、活血化瘀立法的祛湿化瘀方对NASH的临床疗效及基础研究成果,提出＂瘀热蕴结于肝＂是NASH的基本病机。并尝试从NASH的病理特点及祛湿化瘀方的药理靶点进行传统病机理论的现代诠释,以期为中医药防治NASH提供理论依据。

英文摘要：

Non-alcoholic fatty liver disease（NAFLD） has been the major chronic liver disease in China. In recent years, the application of traditional Chinese medicine（TCM） presents some vantage in treating NAFLD. In this review, ＂accumulation and binding of heat-stasis in the liver＂ was identified as the basic pathogenesis of non-alcoholic steatohepatitis（NASH） according to the analysis of clinic typical syndromes and verification through clinical and basic research efficacy of Qushi Huayu decoction which is a Chinese herbal formula used to clear heat, eliminate dampness and remove blood stasis. Meanwhile, rested on the pathologic features of NASH and pharmacological targets of Qushi Huayu decoction, we try to interpret the TCM pathogenetic theory in the modern sense and provide theoretical evidence for the application of TCM to the treatment of NASH.