中文摘要：

目的：寻找一条合成N-[4-（甲氨基）苯甲酰基]-L-谷氨酸二乙酯的最佳方法。方法：以对氨基苯甲酰谷氨酸二乙酯（2）为起始物,经苄基化、甲基化组合成的＂一锅＂反应,高产率地制备了N-[4-（N-苄基-N-甲氨基）苯甲酰基]-L-谷氨酸二乙酯（3）,化合物3经Pd/C催化氢化脱苄基,得到了目标化合物N-[4-（甲氨基）苯甲酰基]-L-谷氨酸二乙酯（1）。结果：合成目标化合物只需2步反应,反应时间仅6h,总产率达到88%,目标化合物通过1HNMR和MS鉴定结构正确。结论：利用上述方法可以方便高效地制备N-[4-（甲氨基）苯甲酰基]-L-谷氨酸二乙酯。

英文摘要：

Objective ：To find a best synthesis method of diethyl N-[p-（methylamino） benzoyl ]-L-glutamate（1）. Methods： Using diethyl N-（p-aminobenzoyl）-L-glutamate （2） as a starting material via a one-pot process of benzylation and methylation, the diethyl N- [ p- （ methyl amino） benzoyl ] -L-glutamate （3） is prepared in high yield. Then compound 1 was conveniently obtained from debenzylation of compound 3 by Pd/C. Results： The target compound was obtained through 2-step reaction in 88% overall yield in only 6 h, and its structure was identified by ^1 HNMR and MS. Conclusion： It is a convenient and efficient method of preparation of diethyl N-[p-（ methyl amino）benzoyl ]-L-glutamate.