中文摘要：

目的探讨白及非多糖组分（白及95%乙醇提取物经D101大孔树脂柱层析水洗脱去除水溶性成分后再用80%乙醇洗脱的组分,BS-80EE）对血小板活化及血液流变学的作用。方法观察不同浓度的BS-80EE给大鼠灌胃后,对大鼠血小板膜糖蛋白CD62P、血小板计数（PLT）、血小板平均体积（MPV）、血小板压积（PCT）和血小板分布宽度（PDW）的影响,并采用扫描电镜观察大鼠血小板的形态变化;同时检测BS-80EE对大鼠血液流变学中各项指标的影响。结果 BS-80EE可剂量依赖性地增加CD62P的活化率;减少PLT、PCT值,对MPV、PDW没有明显作用;各剂量组血小板均伸出长长的伪足,并聚集成团;BS-80EE可使大鼠全血黏度、全血还原黏度、血浆黏度、红细胞聚集指数（EAI）、刚性指数（ERI）及电泳指数（EEI）均增加,变形指数（EDI）降低,对红细胞压积、血沉无显著影响。结论 BS-80EE可通过促进血小板发生活化、形变、聚集,增加血液黏度而发挥止血作用。

英文摘要：

AIM To investigate the effects of a non-polysaccharide fraction of Bletilla striata（ removed aqueous fraction from 95% ethanol extract of Bletilla striata by macroporous resins and then rinsed with 80% ethanol,BS-80EE） on platelet activation and hemorheology. METHODS Rats were given different dosages of BS-80 EE by gavage. The effects of BS-80 EE on platelet activation were assessed by platelet membrane protein molecules CD62P（ CD62P）,platelet count（ PLT）,mean platelet volume（ MPV）,plateletcrit（ PCT） and platelet distribution width（ PDW）,and the platelet morphological changes were observed by scanning electron microscopy. The effects of BS-80 EE on hemorheology indicators in rats were inspected. RESULTS BS-80 EE significantly increased the positive rate of CD62 P and reduced the PLT and PCT,but showed negligible effect on MPV and PDW;BS-80 EE caused platelets to form long pseudopodia,and gathered together; it also significantly increased the whole blood viscosity,whole blood reduced viscosity,plasma viscosity,erythrocyte aggregation index（ EAI）,erythrocyte rigidity index（ ERI）,and erythrocyte electrophoresis index（ EEI）,and decreased erythrocyte deformation index（ EDI）. BS-80 EE did not have significant effects on hematocrit and erythrocyte sedimentation rate（ ESR）.CONCLUSION BS-80 EE can enhance the hemostatic effects by promoting platelet activation,deformation,aggregation and increasing blood viscosity.