中文摘要：

目的探讨负性生活事件与大学生自杀意念的关系及其抑郁的介导作用。方法采用整群抽样方法，调查某综合性大学本科生共1145名，通过症状自评量表（SCL-90）评定大学生近1周内自杀意念和抑郁症状，通过基本情况问卷了解大学生经历的负性生活事件，包括重大疾病、学习困难、经济困难和人际冲突，并通过中介分析探讨抑郁在负性生活事件与自杀意念关系中的介导作用。结果负性生活事件中重大疾病（OR=2．5，P=0．028）、人际冲突（OR=7．2，P=0．002）和经济困难（0R=1．6，P=0．026）均导致自杀意念的产生，学业困难与自杀意念无相关性（OR=1．8，P=0．090）。调整抑郁变量后，重大疾病和人际冲突对自杀意念的影响不再具有统计学意义，而经济困难对抑郁无影响，学业问题对抑郁和自杀意念均无影响，故抑郁是重大疾病和人际冲突与自杀意念的完全中介变量，而抑郁在经济困难、学业问题与自杀意念的关系无中介作用。结论抑郁在不同负性生活事件和自杀意念的关系路径中所起的中介作用不同。

英文摘要：

Objective To understand the relationship between negative life events and suicide ideation, and how it was influenced by the mediating effect of depression. Methods 1145 college students from one university were selected using cluster sampling. Both Symptom Check List （SCL-90） and Qestionnaire were administered to measure depression and suicide ideation in the past week and on the prevalence of negative life events and related information. Recent negative life events would include physical illness, academic problem, financial problem and interpersonal conflict etc. Multiple logistic regressions were used to identify the mediating effect of depression. Results Physical illness （OR=2.5,P=0.028）, interpersonal conflict （OR=7.2,P=0.002） and financial problem （OR = 1.6, P= 0.026） were significantly associated with suicide ideation, but academically-related problems did not seem to be significantly associated with suicide ideation （OR=1.8, P= 0.090）. After adjusted for depression, both physical illness and interpersonal conflicts were not but financial problem remained significantly associated with suicide ideation （OR= 1.7, P =0.014）. Our data showed that depression fully mediated the relationship between physical illness, interpersonal conflict and suicide ideation, but did not mediate the relationship between financial problem and suicide ideation. Conclusion Depression played different mediating roles between different negative life events and suicide ideation. The findings from this study might be able to provide some clues for the prevention interventions on college students.