中文摘要：

Myofibrillogenesis regulator-1 (MR-1 ) 在许多人的癌症通常是基因 overexpressed。然而，房间增长，粘附，移植和染色体宽的基因规定上的 MR-1 的效果仍然是不清楚的。在这研究，一根人的 hepatoma 房间线高度 overexpresses MR-1， BEL-7402/MR-1 房间被建立。当 MR-1 的高表达式没支持房间增长时，它显著地增加了房间与控制房间相比传播，粘附和移植。147 基因的一个总数被 MR-1 表示调整， 46 基因是下面调整的， 101 基因由 MR-1 overexpression 是起来调整的。许多这些基因与房间粘附，细胞骨架规定，发信号的 MAPK，和房间周期有关相关小径。西方的污点分析进一步证实了 MR-1 与移植联系的小径的规定。这些结果建议 MR-1 涉及癌症房间粘附，移植和相关基因表示的规定。

英文摘要：

Myofibrillogenesis regulator-1 （MR-l） is a gene overexpressed usually in many human cancers. However, the effects of MR-1 on cell proliferation, adhesion, migration and genome-wide gene regulation are still unclear. In this study, a human hepatoma cell line that highly overexpresses MR-l, BEL-7402/MR-1 cells was established. While the high expression of MR-1 did not promote cell proliferation, it significantly increased cell spreading, adhesion and migration compared with control cells. A total of 147 genes were regulated by MR-1 expression, 46 genes were down-regulated and 101 genes were up-regulated by MR-1 overexpres- sion. Many of these genes were related to cell adhesion, cytoskeletal regulation, MAPK signaling, and cell cycle related pathways. Western blot analysis further confirmed the regulation of pathways associated with migration by MR-1. These results suggest that MR-1 is involved in the regulation of cancer cell adhesion, migration and related gene expression.