中文摘要：

G3BP（RasGAP SH3domain binding protein）是一种RasGAP SH3结构域特异性结合蛋白,参与Ras下游信号通路,属于RNA结合蛋白家族。G3BP具有核酸内切酶、DNA解旋酶活性,能够诱导应急颗粒的形成,参与多种细胞生长、分化、凋亡和RNA代谢的信号通路。已经发现G3BP在多种肿瘤组织和细胞中高表达,并且与侵袭转移相关。由于G3BP与肿瘤细胞的多种生物学特性有关,因此G3BP有望成为一个肿瘤治疗的新靶点。

英文摘要：

G3BP （Ras-GTPase-activating protein SH3 domain binding protein）,a protein which binds to RasGAP SH3 domain,belongs to RNA-binding protein family,implicating in the downstream of Ras signaling. G3BP harbors the activities of endoribonuclease and DNA helicase,and can induce stress granules formation. G3BP plays a general role in the signal pathways of cell proliferation,differentiation,apoptosis and RNA metabolism. It has been shown to be over-expressed in a number of human malignancies and has a close relationship with tumor invasion and metastasis. Given that it has been implicated in several pathways that are known to be involved in cancer biology,G3BP may provide a new target for cancer therapy.