中文摘要：

采用S/O/W和W/O/W法,和不同的苄丝肼载药量制作缓释微球,用HPLC考察其释放曲线、突释情况和包封率,实验表明S/O/W法制作的苄丝肼微球缓释效果更好,达到了6d,包封率能达到70%以上,突释情况可以接受,苄丝肼载药量低的微球能达到更高的包封率。

英文摘要：

To prepare benserazide-loaded sustained release microsphere using W/O/W and S/O/W method,and with different amount of drug loading.The release was detected by HPLC,and analyzed the drug release,initial burst and the encapsulation efficiency.The results suggest that the microspheres made by S/O/W method work better in sustained release,which reaches 6 days,the encapsula-tion efficiency can be more than 70%,the initial burst is acceptable,and the lower the drug loading is,the higher the encapsulation effi-ciency can be.