中文摘要：

目的：总结丘脑底核脑深部刺激术（DBS）治疗帕金森病（PD）的经验。方法：自2000年3月至2007年12月应用DBS治疗PD137例，其中单侧丘脑底核刺激68例，双侧丘脑底核刺激69例。术后1年（108例）、3年（43例）和5年（20例）分别进行PD评定量表（UPDRS）运动评分。结果：脉冲发生器开启时，在“关”期和“开”期状态下，术后1，3和5年UPDRS运动评分症状改善率分别为55．8％、53．4％和45．2％及22．5％、23．2％和20．4％。手术并发症主要有：肺部感染1例，脉冲发生器植入处胸部皮下感染1例，积液3例，头部刺激电极和皮下导线连接处皮肤破溃1例。二次手术调整刺激电极深度2例。无永久性并发症。结论：掌握适应证，规范手术操作和术中影像学验证是提高DBS疗效，降低并发症的关键。

英文摘要：

Aim： The purpose of this paper was to achieve further improvement of parkinsonian signs and lower complications in deep brain stimulation（DBS） of subthalamic nucleus in Parkinson＇s disease （PD）. Methods： 137 consecutive patients with medically intractable PD underwent subthalamic nucleus stimulation in our department from 2000 to 2007. Unilateral subthalamic nucleus implanting was performed in 68 cases and bilateral subthalamic nucleus implanting in 69 cases. We compared scores on the motor portion of the Unified Parkinson＇s disease rating scale（UPDRS） when the stimulation was turned on or off. Results：When the stimulation was turned on, after operation 1 year（in 108 cases）,3 years（in 43 cases） and 5 years （in 20 cases）, improvement of the UPDRS motor ＂off-medication＂ scores was 55.8%, 53.4% and 45.2% respectively and ＂on-medication＂ was 22.5%, 23.2% and 20.4% respectively. Complications and adverse effects occurred including pneumonia in one case,infraclavicular cutaneous infection in one case, infraclavicular cutaneous fluid collection in 3 cases, head scalp skin erosion in one case and stimulative electrode repositioning in 2 cases, but no serious adverse events and permanent morbidity. Conclusion： A favorable outcome will be expected after careful patient selection, implanting procedure and intraoperative MRI re-scanning.