中文摘要：

鞘脂是细胞生物学功能的重要调控子。重要的鞘脂类分子有促细胞凋亡和抑制细胞增殖的神经酰胺（ceramide,Cer）和鞘氨醇（sphingosine,Sph）,以及促细胞存活的鞘氨醇-1-磷酸（sphingosine 1-phosphate,S1P）。Cer/Sph与S1P之间形成＂鞘脂变阻器＂（sphingolipid-rheostat）,决定细胞的存活或死亡,而鞘氨醇激酶（sphingosine kinases,SphKs）是Cer/Sph与S1P平衡的重要调控分子。本文综述了鞘氨醇激酶1（sphingosine kinase1,SphK1）的生物学特性、其在肿瘤发生发展中的重要作用,以及作为肿瘤治疗靶点的可能性。

英文摘要：

Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide （Cer） and sphingosine （Sph） induce apoptosis and inhibit cell proliferation; on the contrary sphingosine l-phosphate （SIP） promotes cell survival and proliferation. The balance between ceramide/sphingosine and SIP forms a so-called ＂sphingolipid-rheostat＂, which decides the cell fate. Sphingosine kinases, which catalyze the phosphorylation of sphingosine to S1P, are critical regulators of this balance. Here, we review the role of sphingosine kinase 1 （SphK1） in regulating fundamental biological processes and tumorigenesis and the potential of SphK1 as a new target for cancer therapeutics.