中文摘要：

Heme oxygenase-1 (HO-1 ) 系统催化 heme 到生物学上活跃的产品：碳一氧化物， biliverdin/bilirubin 和免费的铁。它涉及维持细胞的动态平衡和生理的许多和 pathophysiological 过程。证据的成长身体显示 HO-1 激活可以在胃肠的道的尖锐、长期的发炎起一个重要保护的作用。这评论在迄今为止学习的胃肠的发炎集中于感应的 HO-1 和它的可能的角色的生理的意义的当前的理解。由药理学工具或用基因治疗的 upregulate HO-1 的能力以后可以为胃肠的发炎提供治疗学的策略。

英文摘要：

Heme oxygenase-1 （HO-1） system catalyzes heme to biologically active products： carbon monoxide, biliverdin/bilirubin and free iron. It is involved in maintaining cellular homeostasis and many physiological and pathophysiological processes. A growing body of evidence indicates that HO-1 activation may play an important protective role in acute and chronic inflammation of gastrointestinal tract. This review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal inflammation studied to date. The ability to upregulate HO-1 by pharmacological means or using gene therapy may offer therapeutic strategies for gastrointestinal inflammation in the future.