中文摘要：

目的考察降糖解郁茶饮防治糖尿病抑郁症作用。方法雄性昆明小鼠随机分为正常组、模型组、阳性药〔盐酸二甲双胍（DMBG,100 mg/kg）、盐酸氟西汀（FH,10 mg/kg）联合用药〕和降糖解郁茶饮低、中、高剂量组（1、2、4 g/kg）,连续灌胃（ig）给药21 d,1次/d,末次给药后1 h进行糖水消耗实验（SCT）、开场实验（OFT）、强迫游泳实验（FST）和血糖测试。结果与正常组比较,模型组小鼠血糖显著升高、糖水偏爱显著降低、游泳不动时间显著增加、OFT运动时间和站立次数显著降低（P〈0.05或P〈0.01）;与模型组比较,降糖解郁茶饮和DMBG＋FH均可使以上异常指标显著改善,二者相比无显著差异。结论降糖解郁茶饮具有防治糖尿病并发抑郁症的作用,且与阳性药DMBG＋FH作用相当。

英文摘要：

Objective To investigate the hypoglycemic and antidepressant-like effects of jiangtang jieyu tea（ JTJYT）. Methods Male mice were divided into normal,model control,DMBG-FH as positive control,low,middle and high doses of JTJYT groups. Mice were treated with DMBG-FH,JTJYT or solvent 0. 5% CMC-Na everyday for 21 days by intragastric administration（ ig）. Mouse sugar consumption test（ SCT）,forced swim test（ FST）,open field test（ OFT） and blood glucose test（ BGT） were used to observe the hypoglycemic and antidepressant-like effects of JTJYT,respectively,at 1 h after the last administration. Results Compared with those of normal group,blood sugar and immobility time of FST were significantly increased,and sucrose preference,moving time and standing times were all significantly decreased. Compared with those of model group,above abnormal parameters were all significantly ameliorated. Conclusions JTJYT exerts hypoglycemic and antidepressant-like effects equal to DMBG-FH.