中文摘要：

目的：制备水溶性双氢杨梅素精氨酸复合物（DAC），拓宽双氢杨梅素（DMY）的给药途径，提高其抗肿瘤活性。方法：取一定量DMY和L-广精氨酸（ARG）在乙醇中回流制备DAC，通过紫外吸收光谱、红外吸收光谱、质谱、核磁共振波谱等方法对DAC进行了结构表征。并采用SRB法对DMY和DAC进行体外抗肿瘤活性考察。结果：物质的量比例为1：1的DMY和ARG形成了DAC，并且干燥的DAC在常温干燥环境下比较稳定。与DMY比较，DAC的水溶性显著增大。10pMDMY和DAC对BGC-823生长的抑制率分别为11．36％、32．67％，对BEL-7402生长的抑制率分别为2．93％、11．33％。结论：该制备方法简捷实用，极大增加了双氢杨梅素的水溶性，有助于提高DMY的生物利用度。抗肿瘤活性测试结果表明，DAC的体外抗肿瘤活性较DMY有所增强。

英文摘要：

Objective： To prepare water - soluble dihydromyricetin arginine compound （DAC）, expand administration route of dihydromyricetin （DMY） and enhance its antineoplasfic activity. Methods： DAC was prepared by refluxing certain amount of DMY and L-arginine in ethanol. DAC was structurally characterized by ultra-violet absorption spectrum, infrared absorption spectrum, mass spectrum 、 nuclear magnetic resonance spectrum. Antineoplastic activity of DMY and DAC was observed by SRB method in vitro. Results： DAC was produced with DMY and arginine with a ratio of 1 ： 1. Dry DAC was relatively stable in a dry, common - temperature circumstance. Solubility of DAC enhanced significantly compared with that of DMY. The inhibition ratios of DMY and DAG （10μM） on BC, C-823 growth were 11.36% and 32.67%, respectively ; in terms of inhibiting growth of BEL-7402, the inhibition ratios of DMY and DAG （10μM） were 2.93% and 11.33% .Conclusions： This preparative method is sample and practical. It increases the solubility of DMY to a great extent, thus contributing to its biological availability. Antineoplastic activity test indicated that the antineoplastic activity of DAC is, to some extent, stronger than that of DMY in vitro.