目前,双相障碍的神经生物学机制尚不明确。双相障碍在免疫性疾病中的发病率较高。研究显示,免疫功能紊乱可能是双相障碍的发病机制之一。本文总结了双相障碍患者中枢神经系统及外周血炎症因子,尤其是辅助性T细胞(Th细胞)相关炎症因子的研究,并且探讨了以Th细胞相关炎症因子为靶点的免疫治疗方法在双相障碍治疗中的研究进展。
The neurobiology of bipolar disorder is not completely known. Bipolar disorder has a high incidence rate in autoimmune diseases. Recent research has presented that immune dysfunction may be one of the pathogenesis of bipolar disorder. The review summarized researches about inflammatory cytokines, especially T helper cells related inflammatory cytokines in periphery and central nervous system in bipolar disorder, and explored the immunotherapy methods with T helper cells related inflammatory cytokines as a promising target in the treatment of bipolar disorder.