中文摘要：

生物防御过氧化损害系统能反映有毒污染物对水环境的早期影响,可作为早期警报指标应用于环境监测中.本文以幼龄鲫鱼为受试生物,研究了较低剂量（1μg/L）的甲基毒死蜱对其肝脏的毒理学效应,分析了29d中鲫鱼的生长指数、肝脏指数以及肝脏抗氧化酶系（包括超氧歧化物歧化酶活性、还原谷胱甘肽含量）和转氨酶活性等随暴露时间的变化趋势,综合考察了各项指标参数.结果表明：该生命体内的保护机制呈现相互竞争和相互代偿合作的关系;谷胱肝肽含量随暴露时间的变化较为显著,可作为敏感的生物标志物.

英文摘要：

The biological system for defensing peroxidation damage could reflect the early influence of toxic pollutants on the water environment, which could be regarded as the early warning index used in the biological monitoring. The findings related to the variation tendency of the effects of methyl ehlorpyrifos （1 /1g/L） to some specific index and major enzymatic activity in crucian＇s liver were described in this study, following the expose time during the different periods in 29 days, including growth index, liver index, antioxidant enzymes activity （superoxygen dismutase and glutathione reductase）, and transaminase activity. From the integrated survey results obtained, there exist protection modes of mutual competition and compensatory coorperation in crucian. Glutathione reductase was recommended as a sensitive biomarker for its marked variation during the exposure periods, and applied in monitoring and evaluating the effect of pollutants to aquatic organisms.