中文摘要：

胚胎干细胞（embryonic stem cells，ES细胞）特异性分子标志是指ES细胞胞内或胞膜上特异表达的分子。已报道的包括转录因子、信号通路受体、黏附因子在内的ES细胞特异性标志与ES细胞的自我更新和全能性具有密切关系。ES细胞特异性分子标志的研究，有助于ES细胞的鉴定、分离纯化、质量控制，加快ES细胞的基础研究和临床应用。现对目前已经发现的ES细胞特异性分子标志及其研究方法和常用ES细胞分子标志的功能进行综述。

英文摘要：

Embryonic stem （ES） cell markers are molecules specifically expressed in ES cells. ES cell markers reported previously including transcription factors, receptors, adhesion molecules and so on, are involved in the mechanism of self-renew and differentiation initiation of ES cells. Approaches such as monoclonal antibody technique, transcriptomics technique and proteomics technique have been used to screen for ES cell markers. ES cell markers play a key role in characterization and isolation of ES cells and elucidation for the mechanism of self- renewal in ES cells, which can finally accelerate the clinical application of ES cells. In this review, we discussed the technology of identification of ES cell markers and the possible function of reported markers to date.