位置：成果数据库 > 期刊 > 期刊详情页
Stereoselective Synthesis of （-）-Chloramphenicol, （＋）-Thiamphenicol and （＋）-Sphinganine via Chiral Tricyclic Iminolactone
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 分类：O641.6[理学—物理化学;理学—化学] TQ453.4[化学工程—农药化工]
  • 作者机构：[1]State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China, [2]College of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China
  • 相关基金：Acknowledgement We are grateful for the National Basic Research Program of China （No. 2011CB833200）, the National Natural Science Foundation of China （Nos. 20772051, 20972058）, the ＂111＂ Program from MOE of P. R. China and the Fundamental Research Funds for the Central Universities （lzujbky-2012-90）.
作者： Qiong Li[1,2], Hongbo Zhang[1], Chenguang Li[1], Pengfei Xu[1]
关键词： 立体选择性合成, 手性中心, 甲砜霉素, 鞘氨醇, 氯霉素, 三环, 羟醛缩合反应, 目标分子, β-hydroxy-a-amino alcohol, tricyclic iminolactone, total synthesis
中文摘要：

stereoselective 综合体()-chloramphenicol,(+)-thiamphenicol 和(+)-sphinganine 被描述。在三个目标分子以内的二个连续 chiral 中心通过 chiral tricyclic iminolactone 和醛的丁间醇醛反应被构造。

英文摘要：

The stereoselective syntheses of （-）-chloramphenicol, （＋）-thiamphenicol and （＋）-sphinganine are described. The two continuous chiral centers within three target molecules were constructed through aldol reaction of chiral tricyclic iminolactone and aldehyde.

同期刊论文项目
基于有机小分子催化的石蒜碱型生物碱的全合成
期刊论文 25 获奖 2
天然产物Lactacystin及其类似物的全合成研究
期刊论文 24 获奖 4
同项目期刊论文
Total Synthesis of Sphingofungin F Based on Chiral Tricyclic Iminolactone
Diastereo- and Enantioselective Synthesis of a Novel Tetracyclic Ring System via an Organocatalytic
Highly Enantioselective Synthesis of Polysubstituted Tetrahydroquinolines via Organocatalytic Michae
A Powerful Cascade Approach for Expeditious Synthesis of Trifluoromethylated Furans
Highly Enantioselective Synthesis of gamma-Nitroketones Containing a Terminal Alkene Moiety by means
Asymmetric Michael Addition of 1-Acetylindolin-3-ones to beta-Nitrostyrenes Catalyzed by Bifunctiona
Organocatalytic enantioselective multicomponent cascade reaction: facile access to tetrahydropyridin
A facile method for synthesis of polysubstituted naphthalene derivatives through pyrrolidine catalyz
Organocatalytic Asymmetric Michael Addition of 1-Acetylindolin-3-ones to alpha,beta-Unsaturated Alde
Hydrogen-Bond-Mediated Supramolecular Iminium Ion Catalysis
Organocatalytic Asymmetric Michael Addition of Oxindoles to Nitroolefins for the Synthesis of 2,2-Di
Concise construction of the tetracyclic core of lycorine-type alkaloids and the formal synthesis of
Organocatalytic Aza-Michael-Michael Cascade Reactions: A Flexible Approach to 2,3,4-Trisubstituted T
Synthesis of Substituted 1,2-Dihydropyridines from Propargyl Vinyl Ethers and Allenic Vinyl Ethers b
Base- and Copper-Catalyzed Intramolecular Cyclization for the Direct Synthesis of Dihydrofurans
Highly Enantioselective Synthesis of γ-Nitroketones Containing a Terminal Alkene Moiety by means of
Synthesis of alpha-Amino Acids Based on Chiral Tricycloiminolactone Derived from Natural (+)-Camphor
Multiple-Organocatalyst-Promoted Cascade Reaction: A Fast and Efficient Entry into Fully Substituted
An asymmetric approach to 5-O-carbamoyl-2-epi-polyoxamic acid and the total synthesis of 2 ''-epi-po
Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-m
Novel Platinum-Catalyzed Tandem Reaction: An Efficient Approach to Construct Naphtho[1,2-b]furan
Development and Application of a New General Method for the Asymmetric Synthesis of (E)-(2-En-3-ynyl
The Application of tert-Butanesulfinamide in the Asymmetric Synthesis of the Core Structure of Polyo
Diastereoselective Synthesis of beta-Substituted-alpha,gamma-Diaminobutyric Acids and Pyrrolidines C
Proline-mediated enantioselective construction of tetrahydropyridines via a cascade Mannich-Type/Int
An Efficient One-Pot Synthesis of omega-Hydroxy Ketones from Lactones
Synthesis and molecular structure of new S-nucleosides of 5-(4-pyridyl)-4-aryl-4H-1,2,4-triazole-3-t
A convenient route to enantiopure 3-aryl-2,3-diaminopropanoic acids by diastereoselective Mannich re
期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175