中文摘要：

目的研究重症肝炎患者肠道IgA、分泌片（SC）和ZO-1、occludin的变化，了解重症肝炎患者伴发腹部症状的原因。方法采用免疫组化方法分别检测肠道IgA、SC和ZO-1、occludin。结果与对照组比较，重症肝炎患者肠道IgA、SC和ZO-1、occludin染色明显减弱。结论重症肝炎患者肠道IgA、SC和ZO-1、occludin表达下降，导致肠道屏障功能发生异常是引起腹部症状的原由之一。

英文摘要：

Objective To study the changes of IgA,secretory component（ SC） and ZO-1 ,occludin of gut in severe hepatitis and to understand the reason of abdomen symptom in severe hepatitis patients. Methods IgA,SC, ZO-1 and occludin of gut were assayed by immunohistochemistry. Results Compared with the controls,the staining of IgA, SC, ZO-1 and occludin in severe hepatitis were notably decreased. Conclusion In severe hepatitis, IgA, SC, ZO-1 and occludin expression of gut decrease, leading to the abnormality of barrier of gut, which is one the reasons of resultings in abdomen symptoms in severe hepatitis.