中文摘要：

在水介质和40℃条件下,碱性蛋白酶催化2,5-二羟基-1,4-二噻烷与N-苯基马来酰亚胺间的Michael-aldol反应,合成了四氢噻吩类化合物,反应取得了93%的产率及3∶1的非对映选择性。该方法具有反应条件温和、反应时间短、后处理简单等优点。

英文摘要：

Tetrahydrothiophene derivatives were synthesized from the Michael-aldol reaction of 1,4-dithiane-2,5-diol and N-phenyl maleimide in water using alkaline protease as a promiscuous catalyst,the yield of 93% and the dr of 3∶ 1 were obtained at 40℃. This method has the advantages of mild reaction conditions,short reaction time,simple post-processing,etc.