中文摘要：

人体内的溶菌酶在第56位、第67位残基发生自发突变的情况下可以通过分子间的聚集形成淀粉样病变,产生一系列的临床症状甚至导致死亡.本研究基于STAMP结构比对算法,使用VMD软件主要从结构角度比较了人、鸡、狗、鼠四种脊椎动物溶菌酶的相似程度及亲缘关系,结果发现鸡的溶菌酶与人的溶菌酶结构最相似,亲缘关系最接近,并且人和鸡的溶菌酶的第56位和第67位两个残基位点在结构上高度保守.该发现为现在流行的以鸡溶菌酶为模型研究人溶菌酶引起的淀粉样病变的致病机制及治愈方法的可行性提供了必要的理论依据.

英文摘要：

Spontaneous mutations of lysozyme at sites Ile56 and Asp67 in human bodies induce amyloid pathological changes through intermolecular aggregration.It may cause a series of clinical symptom and even lead to death.Using VMD（Visual Molecular Dynamics） software,we performed both structure and sequence analysis based on STAMP（Structural Alignment of Multiple Proteins） among lysozymes of four species： human,chicken,dog and mouse.The result represented that lysozymes of human and chicken have the highest similarities. Our results also demonstrate that the corresponding residues of lle56 and Asp67 in chicken and human lysozyme have a highly structural conservation. This will shed light on the study of the mechanisms of amyloid formation caused by lysozyme in human body and curing of the corresponding diseases using chicken lysozyme as an effective model.