中文摘要：

通过抗朊病毒药物筛选模型来筛选治疗以疯牛病为代表的朊病毒疾病的药物是目前国际上研究热点.结合作者正在进行的抗朊病毒药物筛选的研究,主要介绍了国际上流行的几种抗朊病毒药物筛选模型的原理与方法以及研究最新进展.

英文摘要：

The model for antiprion drug dicovery has been a hot research field in sreening drugs for prion diseases,represented by bovine spongiform encephalopathies.Based on the research of antiprion drug screening by the author,this paper mainly introduces the principles and methods of prevailing models for antiprion drug screening and the latest progresses.