中文摘要：

目的：建立失血性休克大鼠模型及探讨失血性休克大鼠肠系膜上动脉（SMA）节律基因表达的变化。方法：建立失血性休克大鼠模型并随机分为失血性休克组和空白对照组,通过RT-PCR检测模型肠系膜上动脉节律基因per1、per2 mRNA的表达水平。结果：休克组与对照组相比,前者肠系膜上动脉节律基因per1、per2的mRNA表达降低（p〈0.05）。结论：失血性休克模型肠系膜上动脉节律基因per1、per2表达水平下调,提示失血性休克可以影响节律基因的表达。

英文摘要：

Objective： To establish the rat model of hemorrhagic shock and to explore the changes of per1 and per2 gene expressions in superior mesenteric artery of rats after hemorrhagic shock.Methods： The rat model of hemorrhagic shock is established.The hemorrhagic shock group and control group were set.The per1 and per2 mRNA expression of SMA were measured by RT-PCR.Results： The level of per1 and per2 mRNA in shock group is lower than in the control group（p0.05）,Conclusion： The per1 and per2 gene expressions in SMA of rats after hemorrhagic shock is decreased,which indicates hemorrhagic shock may affect the expression of circadian genes.