中文摘要：

目的探讨木果楝柠檬苦素类提取物xylocarpin H的抗抑郁活性。方法采用小鼠强迫游泳和悬尾实验评价xylocarpin H的抗抑郁活性,采用开场实验评价xylocarpin H的抗焦虑活性。结果 7 d xylocarpin H灌胃给药显著降低强迫游泳测试中小鼠的漂浮不动时间[空白对照组、xylocarpin H给药组（5 mg/kg、15 mg/kg、50 mg/kg）、文拉法辛给药组分别为（123±5）s、（110±11）s、（105±6）s、（97±6）s、（99±7）s];7 d xylocarpin H灌胃给药显著降低悬尾测试中小鼠的不动时间[空白对照组、xylocarpin H给药组（5 mg/kg、15 mg/kg、50 mg/kg）、文拉法辛给药组分别为（125±7）s、（109±10）s、（103±8）s、（100±6）s、（94±8）s];7 d xylocarpin H灌胃给药显著降低小鼠开场测试中央停留时间[空白对照组、xylocarpin H给药组（5 mg/kg、15 mg/kg、50 mg/kg）、文拉法辛给药组分别为（25±3）s、（39±5）s、（45±9）s、（46±3）s、（43±7）s];同时,xylocarpin H不显著改变小鼠自发活动。结论木果楝提取物xylocarpin H具有显著的抗抑郁和抗焦虑活性,为进一步开发安全有效的抗抑郁药物奠定了实验基础。

英文摘要：

To investigate the antidepressant-like activity of xylocarpin H,a limonoid from Xylocarpus granatum. Methods The forced swimming test（ FST） and tail suspension test（ TST） were used to detect the antidepressantlike activity of xylocarpin H,open field test（ OFT） was performed to evaluate the anxiolytic activity of xylocarpin H in mice.Results The results showed that 7-day continuous administration with xylocarpin H by intragastric gavage decreased significantly the floating time in FST,which in blank control group,xylocarpin H medication administration groups（ 5mg / kg,15 mg / kg,50 mg / kg）,venlafaxine medication administration group was（ 123 ± 5） s,（ 110 ± 11） s,（ 105 ± 6） s,（ 97 ± 6） s,（ 99 ±7） s,respectively. Moreover 7-day continuous administration with xylocarpin H by intragastric gavage decreased obviously the immobility time in TST,which in the five groups as mentioned above was（ 125 ± 7） s,（ 109 ± 10） s,（ 103 ± 8） s,（ 100 ± 6） s,（ 94 ± 8） s,respectively,besides,7d xylocarpin H continuous administration with xylocarpin H by intragastric gavage decreased significantly the residence time in central zone of OFT,which in the five groups was（ 25 ± 3） s,（ 39 ± 5） s,（ 45 ± 9） s,（ 46 ±3） s,（ 43 ± 7） s,respectively. However xylocarpin H had no effects on spontaneous activity of mice. Conclusion The xylocarpin H has obvious antidepressant-like and anxiolytic activities,which may provide an experimental basis for research and development of new antidepressants.