中文摘要：

丝氨酸蛋白酶在已经被广泛研究，而且在一系列广泛的过程具有自身的特点，比如凝固，炎症和消化。现在研究已经证实，这些蛋白在哺乳动物的大脑中很多类型的细胞和区域都有广泛的表达。许多研究显示，大脑和这些蛋白相互作用来调节突触活动和行为相关的一系列过程，并且在脑损伤的病理过程中起到至关重要的作用。因此我们将在本文中讨论丝氨酸蛋白酶在脑损伤中的作用。

英文摘要：

Serine proteases have been intensively investigated in the periphery and their roles in a wide range of processes coagulation, inflammation, and digestion, for example have been well characterized. A growing number of studies demonstrate that these protein systems are widely expressed in many cell types and regions in mammalian brains. Accumulating lines of evidence suggest that the brain has co-opted the activities of these interesting proteins to regulate various processes underlying synaptic activity and behavior, and play a critic role in the pathology of brain injury. In this review, we discuss emerging roles for serine proteases in the regulation of mechanisms underlying brain injury.