中文摘要：

人工骨支架植入人体后主要为细胞提供支撑作用。3D打印技术的出现为组织工程化人工骨支架结构的设计、制造与优化提供了新的方法。为研究磷酸钙骨水泥（Calcium Phosphate Cement,CPC）人工骨支架的微孔分布及孔隙率与力学性能的关系,设计了3种不同主流道模型,并在原始模型的基础上对微孔道进行了细化,分别建立这些具有不同孔隙率的支架结构模型,采用Ansys Workbench对这些模型进行有限元分析,提取各个模型的最大等效应力和最大总变形,综合分析支架微孔的分布及孔隙率与上述参数的关系。结果显示,支架的力学性能与微孔道的分布有着紧密的关系,对于同种模型,随着孔隙率的增大,支架的最大总变形呈递增趋势,但不同模型的上述参数对孔隙率的敏感性存在一定的区别。分析结果为后续通过3D打印技术制备生物陶瓷人工骨支架提供了参考依据。

英文摘要：

Artificial bone scaffolds provide support for cells after implantation in the human body. The emergence of 3D printing technology provides a new method for the design, manufacture and optimization of artifwial bone scaffolds structure. In order to study the relationship among microchannel distribution ＂and porosity and mechanical properties of scaffolds made by Calcium Phosphate Cement, three models with different main channels were designed, and the micrachannels were elaborated based on the original scaffolds, to establish these scaffolds structure models with different porosity, and Ansys Workbench was used to do the finite element analysis of scaffolds structure models, and calculate the maximum equivalent stress and the maximum total deformation of each model. Then the relationship between the scaffolds microchannel distribution and porosity and these parameters was analyzed. Results showed that the mechanical properties of scaffolds has close relationship with the distribution of the microchannel, for the same model, with the increasing of the porosity, the maximum total deformation showed a trend of increasing. But the sensitivity of the above parameters of different models on porosity has certain difference. Analysis results are useful for building artificial bone by 3D printing process.