中文摘要：

慢性炎症为肿瘤发生的关键促进因子，炎症相关基因腺苷酸活化蛋白激酶（AMPK）、核因子κB（NF—κB）、环加氧酶2（COX-2）、前列腺素E2（PGE2）在非小细胞肺癌（NSCLC）细胞增殖、凋亡、转移过程中起着重要作用，它们之间相互调节，启动相关信号通路，共同参与肿瘤细胞的发生、发展，促进NSCLC细胞的增殖和迁移。研究AMPK／NF-κB／COX4／PGE2在NSCLC发生、发展中的相互关系，可能为NSCLC的诊断、治疗及预后判断提供新的分子标志物，为NSCLC的三级预防奠定理论与实验基础。

英文摘要：

Abstract： Chronic inflammation is a key tumor promoting factor,and inflammation-related genes adenosine-monophosphate-activated protein kinase （ AMPK ）, nuclear factor κB （ NF-κB ）, cyclooxygenase-2 （ COX-2 ） and prostaglandin E2 （ PGE2 ） play important roles in the proliferation, apoptosis and metastasis of non-small cell lung cancer（ NSCLC ） that their interactions and related signaling pathways are involved in the development and progression of tumor cells. They promote the proliferation and migration of NSCLC cells con- tinuously. The studies on AMPK,NF-κB, COX-2 and PGE2 in the development of NSCLC may provide new molecular markers of the diagnosis, treatment and prognosis, establishing theoretical and experimental basis for the tertiary prevention of NSCLC.