中文摘要：

应用UPLC-MS—MS系统研究盐酸阿比朵尔在实验动物大鼠体内的代谢情况，利用超高效液相色谱的分离能力结合串联质谱的质量分辨性能，以药物分子结构中的同位素现象为指针，共检测和鉴定出盐酸阿比朵尔在大鼠体内的代谢产物9种，其中I相代谢产物2种，II相代谢产物7种，并包括两对非对映异构体。实验结果揭示药物在大鼠体内主要经过N-脱烷基化、S-氧化、O-葡糖醛酸轭合和O-硫酸酯化轭合等代谢反应。

英文摘要：

UPLC-MS-MS system was used for the identification of arbidol metabolites in the rat feces, urine and plasma samples. The system was so powerful a way with high ability of separation and analysis, based on both chromatography and mass properties. The isotope of Br was also a good indicator for metabolites finding. There were altogether 9 metabolites detected and identified, including 2 phase I biotransformation products and 7 phase II ones. It is concluded that arbidol mainly undergo metabolic reactions such as N-demethylation, S-oxidation, glucuronidation and sulfation in rats.