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Effects of Aluminum Trichloride on Structure and Function of Kidney in Chickens
  • 期刊名称：Journal of Northeast Arricultural University
  • 时间：2012.3.31
  • 页码：83-86
  • 分类：S896.6[农业科学—特种经济动物饲养;农业科学—畜牧兽医]
  • 作者机构：[1]黑龙江省科技厅,哈尔滨150008, [2]哈尔滨维科生物技术开发公司,哈尔滨150069, [3]黑龙江省森工林区兽医卫生防疫站,哈尔滨150008, [4]东北农业大学动物医学院,哈尔滨150030
  • 相关基金：国家自然基金项目（31172375）
  • 相关项目：铝免疫毒性的神经内分泌调控机制
作者： BAI Chongsheng|HAN Yanfei|XIA Shiliang|LI Yanfei|
关键词： 亚慢性, 铝暴露, 大鼠, 肾脏结构
中文摘要：

选用40只4周龄清洁级Wistar大鼠预饲一周后随机均分为4组，即对照组（C组）、低剂量组（L组）、中剂量组（M组）和高剂量组（H组）。分别于饮水中添加0，64．18，128．36，256．72mg／kg·bw的AlC13，建立亚慢性铝暴露大鼠模型。于实验120d处死大鼠，取肾脏，进行脏器系数测定和HE染色观察病理变化。结果表明．各染铝组脏器系数均显着高于c组（P〈0.01），随染铝剂量的升高脏器系数降低，呈剂量一效应关系。染铝可致肾小管腔变窄，管腔结构消失，上皮细胞融合，核消失；肾小囊消失。肾小球萎缩；肾小球血管扩张，呈分中状；随染铝的剂量升高，肾小球坏死程度逐渐加重。上述结果说明，亚慢性铝暴露可致大鼠肾脏组织病理性损伤。

同期刊论文项目
铝免疫毒性的神经内分泌调控机制
期刊论文 38 著作 1
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