中文摘要：

目的 ：应用二维斑点追踪显像评价左心室收缩功能正常的高血压患者的左心房功能,探讨左心房功能与左心室重构之间的关系。方法：常规采集102例高血压患者及102例年龄、性别匹配的正常人二维超声心动图。获得左心房主动收缩前的容积（LAVpre A）、最小容积（LAVmin）及最大容积（LAVmax）等数据。分别计算出左心房排空分数[（LAVmax-LAVmin）/LAVmax]、被动排空分数[（LAVmax-LAVpre A）/LAVmax]及主动排空分数[（LAVpre A-LAVmin）/LAVpre A],应用GE Echo PAC得出左心房收缩期、舒张早期及舒张晚期各壁的速度（Vs、Ve、Va）、应变（εs、εe、εa）及应变率（SRs、SRe、SRa）。结果：高血压患者的收缩期、舒张早期及舒张早期左心房整体应变、应变率及速度均显著低于正常对照组（P〈0.01）。高血压患者的左心房最大容积、收缩期前容积及最小容积皆显著大于正常对照组（P〈0.000 1）,排空分数显著降低（P〈0.05）;左心房整体二维应变参数与左心房的容积呈显著负相关,与排空分数呈显著正相关,与左心室质量指数呈显著负相关。结论：与正常对照组比较,高血压患者左心房容积明显增大,功能显著降低,且与左心室重构显著相关。

英文摘要：

Objective：We aimed to assess the left atrial（LA） myocardial function using two-dimensional（2D） speckle tracking echocardiography（STE） in hypertension patients with preserved LV ejection fraction and to explore the relationship between LV remodeling and LA function. Methods：The routing 2D echocardiography data sets were acquired of 102 hypertensive patients and102 age and gender matched normal subjects. Preatrial contraction volume（LAVpre A）, minimal LA volume（LAVmin） and maximal LA volume（LAVmax） were measured. LA EF[（LAVmax-LAVmin） / LAVmax],passive[（LAVmax-LAVpre A） / LAVmax] and active empty EF [（LAVpre A-LAVmin） / LAVpre A]were calculated. The LA strain during systole,early and late diastole（εs,εa and εe =εs-εa）;srtrain rate（SRs,SRe and SRa） and velocity（Vs,Ve and Va） were analyzed by GE Echo PAC. Results：Global LA εs,εe,and εa,SRs,SRe and SRa as well as Vs,Ve and Va were significantly lower in patients than control group（P 〈0.000 1,except εa,which the P was 0.006）. The LAVmax,LAVpre A,LAVmin were significantly higher in patients than controls（P 0.000 1）,and empty EF was statistically lower in patients than normal（P 〈0.05）. The global LA 2DSTE parameters were significantly correlated with LA volumes and empty EF,which represented LA function. The global LA Ve / Va was significantly correlated LV mass index（r=-0.39,P 〈0.0001）. Conclusion：Our results indicated that the LA volumes were increased and functions were decreased,which were related with LV remodeling in patients with hypertension.