中文摘要：

目的：探讨重症肌无力（MG）患者血清抗乙酰胆碱受体抗体（AchRab）和抗突触前膜抗体（Psmab）水平与其临床特征之间的关系。方法：采用ABC—ELISA法检测186例MG患者及35例正常人血清AchRab和Psmab。结果：MG患者血清AchRab和Psmab水平及阳性率均高于对照组（P〈0．01），且2抗体水平高度相关（r=0．72，P〈0．001）。2抗体水平与MG患者的性别无关；1～14岁患者2抗体水平较低；胸腺瘤患者2抗体水平高于胸腺增生者；危象型患者高于轻型和混合型患者；手术摘除胸腺后，2抗体水平较术前下降（P均〈0．05）。结论：AchRab和Psmab与MG患者病情程度及病理类型有关，可用于MG的病情监测。

英文摘要：

Aim： To study the relationship between the serum contents of acetylcholine receptor antibody（AchRab） and anti-presynaptic membrane antibody（Psmab） and the clinical features of myasthenia gravis （MG） patients. Methods ： Serum contents of AchRab and Psmab of 186 cases of MG and 35 normal controls were determined with ABC-ELISA. Results： The levels and the total positive rate of serum AchRab and Psmab in MG were significantly higher than those in control group（P 〈 0. 01 ） ,and there was a positive correlation between AchRab and Psmab. The levels of both antibodies were significanly higher in patients aging from 1 - 14 years old than those in patients aging more than 14 years old, and those in MG patients with thymoma were significantly higher than those with hyperplastic thymus. The levels of serum AchRab and Psmab in patients of IV and Vtype were higher than those of Ⅰ -Ⅱ type. Conclusion：The serum contents of AchRab and Psmab are correlated with the severity and pathological types of MG patients and may be a laboratory parameter for the diagnosis of MG.