中文摘要：

Mov10蛋白属于RNA解旋酶超家族-1,是RNA-诱导沉默复合体的组成成分之一。Mov10蛋白在介导miRNA/siRNA基因沉默中有积极的作用,其确切机制尚不清楚。研究证实,Mov10蛋白具有广泛和有效的抗逆转录病毒活性,能在多阶段抑制HIV-1复制,包括病毒产生、Gag蛋白水解程序、逆转录过程;同时也可降低其他逆转录病毒如猿类免疫缺陷病毒、鼠白血病病毒和马传染性贫血病毒的感染性。新近研究发现Mov10在肿瘤中表达升高,推测其与hTERT和端粒相关,参与肿瘤的形成和肿瘤细胞的分化。

英文摘要：

Mov10 protein is a member of RNA helicase-1 superfamily, and it is also one of the components of the RNA-induced silencing complex. Mov10 plays an important role in miRNA/siRNA-induced gene silencing, but the exact mechanism remains unknown. Studies have show that Mov10 protein widely and potently inhibits HIV-1 replication at multiple stages, including virus production, proteolytic processing of Gag, and reverse transcription. Meanwhile, Mov10 can reduce the infectivity of other retrovirus such as simian immunodeficiency virus, murine leukemia virus and equine infectious anemia virus. Recent research described that Mov10 overexpressed in tumors and speculated to involve carcinogenesis and differentiation relating to hTERT and telomere.