中文摘要：

糖皮质激素诱导的肿瘤坏死因子受体配体（glucocorticoid-induced tumor necrosis factor receptor ligand,GITRL）是TNF家族新成员,与糖皮质激素诱导的肿瘤坏死因子受体（GITR）结合后,提供正向的刺激信号,参与T细胞反应。与其他TNF家族成员不同的是：hGITRL胞外功能区自身聚集形成疏松的三聚体结构,而mGITRL则表现出独特的二聚体结构。在溶液中,GITRL通过寡聚化作用形成多种形式的低聚体,通过寡聚化作用可以调节低聚体的数量,优化GITRL/GITR信号的发挥。此外,GITRL还可以通过传递反向信号发挥其独特的生物学功能。

英文摘要：

Glucocorticoid-induced TNF receptor ligand （GITRL）, a recently identified member of the TNF superfamily, binds to its receptor, GITR, and generates positive costimulatory signals implicated in a wide range of T cell functions. In contrast to all previously characterized homotrimeric TNF family members, hGITRL forms a loosely assembled open trimer, while mGITRL crystal structure reveals a previously unrecognized dimeric assembly. GITRL exists as an equilibrium between different oligomers. This dynamic equilibrium may represent a mechanism to realize the biologically optimal level of signaling through the GITRL/GITR pathway. In addition, GITRL can also provide a reverse signaling just like other TNF superfamily members.