中文摘要：

利用正硅酸乙酯在W／O乳液中的原位水解聚合，成功制备了包埋井冈霉素的二氧化硅载药空心微球．对所得产品进行了SEM，XRD，FT-IR和粒径分布等分析，结果表明，载药空心微球粒径分布窄，范围在7．5-15μm，球状形貌良好，具有空心结构，呈无定型态．热重分析表明载药空心微球的药物负载量约为31．9％（ω），缓释溶出实验显示载药空心微球药物释放持续时间约240min，最终释放量达总载药量的90％以上．

英文摘要：

Validamycin-loaded silica hollow microspheres were prepared by in situ hydrolysis of tetraethyl orthosilicate （TEOS） in Water-Oil （W/O） emulsions. The microspheres were characterized by SEM, XRD, FT-IR and particle size distribution. The results indicated that the drug-loaded microspheres had an amorphous hollow spherical structure with the diameters of 7.5-15 μm. The amount of validamycin entrapped in the microspheres was about 31.9%（ω）. Sustained-releasing studies showed that the release time was about 240 rain and more than 90% of the loaded drug in the microspheres was delivered, indicating good sustained release behavior of the drug-loaded microspheres.