中文摘要：

在乳腺癌发生发展过程中，雌激素受体（estrogen receptor α．ERα）信号途径的活性增强，一个重要的原因是ERα共调节因子的变化。ERα共调节因子可分为共激活子和共抑制子。本文对ERα共激活子的种类、与ERα的结合方式、作用机制及其与乳腺癌的关系进行了综述。

英文摘要：

During the development of breast cancer, the activity of estrogen receptor α （ERα）signaling pathway can be enhanced. One of the important reason is the change of ERα coregulors. The coregulators can be divided into coactivators and corepressors. The present review iocuses on the Ella coac-tivator in combining with ERα, with a specific emphasis on the ERα activator activities in breast cancer.